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Radiation therapy

Sensitizing stem cells

Nature Reviews Cancer volume 8, pages 246–247 (2008)Cite this article

The authors chose several mouse models of medulloblastoma for study, all of which were wild-type for p53, which is known to have a role in the response to therapy. In each of the models, they used histological staining to characterize three distinct cell populations: the moderately proliferating perivascular niche, which expressed nestin, a stem cell marker, and two populations in the tumour bulk, one highly proliferating and a smaller population that was relatively quiescent. When a dose of radiation equivalent to that used in therapy was applied, only the highly proliferating tumour bulk cells underwent apoptosis. By contrast, the nestin-expressing cells went into cell-cycle arrest within 6 h of irradiation but then re-entered the cell cycle at 72 h.

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ORIGINAL RESEARCH PAPER

  1. Hambardzumyan, D. et al. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medullolastoma in vivo. Genes Dev. 22, 436–448 (2008)

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  1. Patrick Goymer
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Goymer, P. Sensitizing stem cells. Nat Rev Cancer 8, 246–247 (2008). https://doi.org/10.1038/nrc2358

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  • DOI: https://doi.org/10.1038/nrc2358

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