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Genetics as a tool to improve cancer outcomes: ethics and policy

Abstract

Genetic research is rapidly increasing the opportunities for the detection of inherited cancer risk. Clinicians and policy makers must ensure the adequate evaluation of the benefits and harms of this new area of practice, address the challenges of family-based detection of individuals at risk and develop practice guidelines and educational strategies that are responsive to rapidly changing knowledge. When the benefits of testing are well established, efforts must also be made to ensure access to genetic services for all who can benefit.

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Acknowledgements

Supported in part by grants from the US National Institutes of Health.

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Correspondence to Wylie Burke.

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The authors declare no competing financial interests.

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DATABASES

National Cancer Institute

Brain tumour

Breast Cancer

Colorectal Cancer

Leukaemia

Ovarian Cancer

thyroid cancer

OMIM

multiple endocrine neoplasia type 2

familial adenomatous polyposis

FURTHER INFORMATION

National Institute for Health and Clinical Excellence

GeneTests

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Burke, W., Press, N. Genetics as a tool to improve cancer outcomes: ethics and policy. Nat Rev Cancer 6, 476–482 (2006). https://doi.org/10.1038/nrc1890

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