Epidemiological studies indicate that stress, chronic depression and lack of social support might serve as risk factors for cancer development and progression. Recent cellular and molecular studies have identified biological processes that could potentially mediate such effects. This review integrates clinical, cellular and molecular studies to provide a mechanistic understanding of the interface between biological and behavioural influences in cancer, and identifies novel behavioural or pharmacological interventions that might help improve cancer outcomes.
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The authors gratefully acknowledge the support of several Institutes and Centers of the National Institutes of Health; National Cancer Institute (M.H.A., S.K.L., F.S.D., and A.K.S.), National Center for Complementary and Alternative Medicine (S.K.L.), National Institute of Allergy and Infectious Diseases (S.W.C. and F.S.D.) and National Institute of Mental Health (M.H.A.). The authors also acknowledge support received from the Dana Foundation (F.S.D.), Jonssen Comprehensive Cancer Center (S.W.C.) and Norman Cousins Center at the University of California, Los Angeles (S.W.C.). Preparation of this perspective was facilitated by support from the Division of Cancer Control and Populations Sciences at the National Cancer Institute. We are indebted to Wendy Nelson for her editorial review of the manuscript.
The authors declare no competing financial interests.
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Antoni, M., Lutgendorf, S., Cole, S. et al. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 6, 240–248 (2006). https://doi.org/10.1038/nrc1820
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