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RAS oncogenes: the first 30 years

A Correction to this article was published on 01 September 2003


From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction — mainly in human cancer — is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.

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Figure 1: Schematic representation of our current view of RAS regulation.
Figure 2: Overview of known RAS effectors and their corresponding biological responses.


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Correspondence to Marcos Malumbres or Mariano Barbacid.

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Malumbres, M., Barbacid, M. RAS oncogenes: the first 30 years. Nat Rev Cancer 3, 459–465 (2003).

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