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Tumour budding in colorectal cancer: molecular rationale for clinical translation

Nature Reviews Cancer volume 18, pages 203204 (2018) | Download Citation

Precision medicine and personalized health care call for reproducible and standardized predictive and prognostic biomarkers that can influence the clinical management of patients with cancer. In colorectal cancer, tumour budding — a histological manifestation of tumour cell invasion that is likened to epithelial–mesenchymal transition — is now emerging as one such factor.

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The authors would like to acknowledge J. R. Jass, our friend and mentor who inspired much of the original works on tumour budding in CRC, as well as our colleagues from the International Tumour Budding Consensus Conference.

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  1. Institute of Pathology, University of Bern, Bern, Switzerland.

    • Inti Zlobec
    •  & Alessandro Lugli


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The authors declare no competing financial interests.

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Correspondence to Inti Zlobec.

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