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Tumour budding in colorectal cancer: molecular rationale for clinical translation

Precision medicine and personalized health care call for reproducible and standardized predictive and prognostic biomarkers that can influence the clinical management of patients with cancer. In colorectal cancer, tumour budding — a histological manifestation of tumour cell invasion that is likened to epithelial–mesenchymal transition — is now emerging as one such factor.

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  1. 1

    Lugli, A. et al. Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Mod. Pathol. 30, 1299–1311 (2017).

    Article  Google Scholar 

  2. 2

    Rogers, A. C. et al. Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer. Br. J. Cancer 115, 831–840 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Grigore, A. D., Jolly, M. K., Jia, D., Farach-Carson, M. C. & Levine, H. Tumor budding: the name is EMT. Partial EMT. J. Clin. Med. (2016).

  4. 4

    De Smedt, L. et al. Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching. Br. J. Cancer 116, 58–65 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Knudsen, K. N., Lindebjerg, J., Nielsen, B. S., Hansen, T. F. & Sorensen, F. B. MicroRNA-200b is downregulated in colon cancer budding cells. PLOS One 12, e0178564 (2017).

    Article  Google Scholar 

  6. 6

    Galvan, J. A. et al. TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. Oncotarget 6, 874–885 (2015).

    Article  Google Scholar 

  7. 7

    Bronsert, P. et al. Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface. J. Pathol. 234, 410–422 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Centeno, I. et al. DNA profiling of tumor buds in colorectal cancer indicates that they have the same mutation profile as the tumor from which they derive. Virchows Arch. 470, 341–346 (2017).

    Article  Google Scholar 

  9. 9

    Lugli, A. et al. CD8+ lymphocytes/ tumour-budding index: an independent prognostic factor representing a 'pro-/anti-tumour' approach to tumour host interaction in colorectal cancer. Br. J. Cancer 101, 1382–1392 (2009).

    CAS  Article  Google Scholar 

  10. 10

    Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cells — an integrated concept of malignant tumour progression. Nat. Rev. Cancer 5, 744–749 (2005).

    CAS  Article  Google Scholar 

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The authors would like to acknowledge J. R. Jass, our friend and mentor who inspired much of the original works on tumour budding in CRC, as well as our colleagues from the International Tumour Budding Consensus Conference.

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Correspondence to Inti Zlobec.

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The authors declare no competing financial interests.

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Zlobec, I., Lugli, A. Tumour budding in colorectal cancer: molecular rationale for clinical translation. Nat Rev Cancer 18, 203–204 (2018).

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