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The non-redundant nature of adenosinergic molecules is tested in this study for the first time and highlights the potential to co-target CD73 and A2AR molecules in cancer treatment.
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This is a critical paper that thoroughly delineates host and tumour-intrinsic roles of A2BR in the progression of metastasis through the use of A2BR- deficient mice and A2BR-knockdown tumour cells.
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The potential to use the combination of CAR T cells with A2AR inhibition is demonstrated in this study.
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This study highlights a role for CD73 as a prognostic marker of patient survival and as a candidate therapeutic target in advanced serous ovarian cancers.
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This study demonstrates the preclinical efficacy of MEDI9447, a cross-reacting CD73 mAb that is currently undergoing a phase I clinical trial.
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This is an informative study that demonstrates a previously unrecognized role for CD39 in the dephosphorylation of T cell phosphoantigens.
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This study shows the first preclinical demonstration that targeting CD73 might be an effective cancer therapy.
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This study shows that CD73 expression in the prostate epithelium suppresses immunosurveillance by CD8+ T cells, whereas CD73 expression in the tumour stroma reduces NF-κB signalling in tumour cells via A2BR signalling.
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This study shows that CD73-generated adenosine promotes epithelial integrity and suggests why loss of CD73 in endometrial cancer enables tumour progression.