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Tumour metabolism

Reflecting their origins

Nature Reviews Cancer volume 16, pages 676–677 (2016)Cite this article

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Mayers, Torrence et al. investigated whether the tissue of origin affects branched-chain amino acid (BCAA) metabolism, as elevated plasma levels of BCAAs are present in mice with pancreatic ductal adenocarcinoma (PDAC) but not in non-small-cell lung cancer (NSCLC) induced by oncogenic KRAS and loss of p53. KrasG12D/+;Trp53flox/flox (KP) mice were either crossed with a pancreatic and duodenal homeobox 1 (Pdx1) promoter-driven Cre strain to induce Trp53 knockout in the pancreas or given viral Cre in the lungs to generate PDAC and NSCLC tumours, respectively. The authors fed the mice with 13C-labelled BCAAs (leucine and valine), and levels of BCAA metabolites were measured. NSCLC tumours had higher levels of labelled BCAAs relative to normal lung tissue, whereas PDAC tumours did not (compared with normal pancreas), suggesting that lung tumours have higher uptake of BCAAs.

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References

  1. Mayers, J. R., Torrence, M. E. et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 353, 1161–1165 (2016)

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  1. Sarah Seton-Rogers
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Seton-Rogers, S. Reflecting their origins. Nat Rev Cancer 16, 676–677 (2016). https://doi.org/10.1038/nrc.2016.106

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  • DOI: https://doi.org/10.1038/nrc.2016.106

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