Single nucleotide polymorphisms (SNPs) in LIM domain only 1 (LMO1) are known to be associated with increased risk of neuroblastoma. Oldridge et al. have now found that the SNP rs2168101G>T is most highly associated with neuroblastoma and is found within a super-enhancer in intron 1 of LMO1. The T allele is associated with reduced neuroblastoma risk and ablates binding of the GATA3 transcription factor to the super-enhancer. Therefore, differential GATA transcription factor activity may underlie neuroblastoma risk.