a,b, Rotarod analysis of wild-type or CMT-1B females (a) or males (b) mice of indicated age following orally gavage (twice daily) with Sephin1 (1 mg/kg) or vehicle. Data are means of three trails performed on the same day ± SEM (n=4-8). The data shown here are the same as in Figure 1 but the analysis were performed separating genders. No samples, mice or data points were excluded from the analyses. All data shown were collected while conforming to governmental and institutional guidelines for care and use of laboratory animals. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001; (males F(1,14)=13.55, p=0.0025; females F(1,14)=9.38, p=0.0091).