Figure 5

From: Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats

Figure 5

Freezing rates across (a) the three extinction sessions (Ext 1, 2, and 3) and extinction retention test (ERT, day 16) and (b) social interaction (SI) time (day 17) of rats treated with SR141716 (SR, 1 mg/kg) or vehicle (Veh) 30 min before, and with URB597 (0.1 mg/kg, URB 0.1) or vehicle immediately after the extinction sessions on day 7, 10, and 13. Freezing rates across (c) the three extinction sessions and extinction retention test (day 36) and (d) social interaction time (day 37) of rats treated with SR141716 (1 mg/kg) or vehicle 30 min before, and with URB597 (0.1 mg/kg) or vehicle immediately after the extinction sessions on day 7, 10, and 13. *P<0.05, **P<0.01, Veh/URB 0.1 vs Veh/Veh; +P<0.05, ++P<0.01, Veh/URB 0.1 vs SR/Veh; #P<0.05, Veh/URB 0.1 vs SR/URB 0.1; §P<0.05, §§P<0.01, Veh/URB 0.1 vs each other group). Data are expressed as mean+SEM (n=8–10 per group).