Figure 4

From: Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats

Figure 4

Freezing rates across (a) the three extinction sessions (Ext 1, 2, and 3) and extinction retention test (ERT) and (b) social interaction (SI) time of rats treated with URB597 (0.1 mg/kg; URB 0.1 Shock) or vehicle (Veh Shock) immediately after the extinction sessions on day 7, 10, and 13, exposed to the traumatic experience (Exp) or never presented the shock but only exposed to the experimental context (Context Exp; URB 0.1 No Shock, Veh No Shock). (c) Freezing rates of rats exposed to the shock experience (Exp), but not to the extinction sessions and treated with URB597 or vehicle on day 7, 10, and 13, as assessed during the retention session (RT) on day 16. (d) Social interaction time of the same rats during the SI test on day 17. ^P<0.05, Veh Shock vs Veh No Shock; *P<0.05, URB 0.1 Shock vs Veh Shock; P<0.05, URB 0.1 Shock vs URB 0.1 No Shock. Data are expressed as mean±SEM (n=7–11 per group).