The obesity epidemic in the US and abroad has increased interest in neurobiological mechanisms that contribute to eating in the absence of energy demand or hunger (overeating). Overeating, sometimes called ‘hedonic’ feeding because foods consumed are usually palatable and high in sugars and fats, is the leading cause of overweight and obesity in the US. One important factor that contributes to obesity is overeating triggered by sights, sounds, and smells (food cues) associated with palatable food (Stice et al, 2013; Tang et al, 2012). For example, obese and overweight people report greater food craving and consume larger portions in response to food cues. A wealth of preclinical studies have demonstrated that these cue-triggered motivational responses are mediated by brain mesocorticolimbic circuits, particularly dopamine and glutamate transmission within the nucleus accumbens (NAc). In humans, the magnitude of activations in the NAc in response to food cues predicts future weight gain in normal-weight people and inability to lose weight after obesity onset. This suggests that differences in NAc function may mediate enhanced cue-triggered urges to eat in susceptible individuals both before and after weight gain. The overlap in the neural systems involved and similarities between responses to food, addictive drugs, and cues associated with them have sparked vibrant discussion about ‘food addiction’ (Carter et al, 2016), despite some obvious differences between food and drug (eg, food does not have psychoactive properties in the pharmacological sense, nor is there a clear dose-response relationship, etc.). So, can overeating that produces common obesity really be considered a form of addiction?
In a recent preclinical study we found that, prior to any diet manipulation, those rats that show the strongest motivational responses to a food cue subsequently gained the most weight when given free access to a fatty, sugary, ‘junk-food’ diet (Robinson et al, 2015). Obesity-prone rats are also more sensitive to the locomotor-activating effects of cocaine, indicating enhanced responsivity of mesolimbic systems, and have greater excitability of medium spiny neurons in the NAc core prior to the development of obesity (Oginsky et al, 2016a, b). Taken together, our data suggest that pre-existing enhancements in NAc responsivity may render obesity-susceptible individuals more sensitive to the motivational properties of food cues. In addition, consumption of fatty, sugary foods alters NAc function in ways that also vary by susceptibility to obesity. For example, consumption of junk food enhances NAc glutamatergic transmission and produces an upregulation of calcium-permeable AMPA receptors (CP-AMPARs) in obesity-susceptible rats (Brown et al, 2015; Oginsky et al, 2016a). Interestingly, increases in CP-AMPARs were found prior to obesity onset, suggesting that they may drive enhanced motivational responses that promote weight gain (see Oginsky et al, 2016b for further discussion).
Enhanced cue triggered motivation and accompanying increases in NAc responsivity are thought to underlie drug addiction (Flagel et al, 2009), and NAc CP-AMPARs mediate enhanced cue-trigged cocaine-seeking (Wolf, 2016). One pressing question that arises, however, is the extent to which the enhanced neurobehavioral responsivity found in obesity-susceptible rats is a form of aberrant motivation, akin to drug addiction. Brain reward circuits evolved in part to direct behavior towards food. Thus, enhancements in NAc responsivity and cue-triggered motivation could be described as an improved function of this system (ie, rendering individuals better able to find food) rather than dysfunction. Of course, not being able to curb cue-triggered urges in the current calorie-dense food environment is unhealthy, and it is not entirely clear where this idea leaves obesity-resistant individuals. Are they the outliers? However, to develop better prevention strategies for obesity it will be important to differentiate ‘normal’ neurobehavioral responses from fundamentally aberrant ones and to continue to challenge ourselves by asking these questions.
Funding and Disclosure
Funding to CRF is provided by NIDDK R01DK106188 and a NARSAD young investigator award. The author declares no conflict of interest.
Brown RM, Kupchik YM, Spencer S, Garcia-Keller C, Spanswick DC, Lawrence AJ et al (2015). Addiction-like synaptic impairments in diet-induced obesity. Biol Psychiatry. (e-pub ahead of print; doi:10.1016/j.biopsych.2015.11.019).
Carter A, Hendrikse J, Lee N, Yucel M, Verdejo-Garcia A, Andrews Z et al (2016). The neurobiology of ‘food addiction’ and its implications for obesity treatment and policy. Annu Rev Nutr 36: 105–128.
Flagel SB, Akil H, Robinson TE (2009). Individual differences in the attribution of incentive salience to reward-related cues: implications for addiction. Neuropharmacology 56 Suppl 1: 139–148.
Oginsky MF, Goforth PB, Nobile CW, Lopez-Santiago LF, Ferrario CR (2016a). Eating ‘junk-food’ produces rapid and long-lasting increases in NAc CP-AMPA receptors; implications for enhanced cue-induced motivation and food addiction. Neuropsychopharmacology (e-pub ahead of print; doi:10.1038/npp.2016.111).
Oginsky MF, Maust JD, Corthell JT, Ferrario CR (2016b). Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity. Psychopharmacology 233: 773–784.
Robinson MJ, Burghardt PR, Patterson CM, Nobile CW, Akil H, Watson SJ et al (2015). Individual differences in cue-induced motivation and striatal systems in rats susceptible to diet-induced obesity. Neuropsychopharmacology 40: 2113–2123.
Stice E, Figlewicz DP, Gosnell BA, Levine AS, Pratt WE (2013). The contribution of brain reward circuits to the obesity epidemic. Neurosci Biobehav Rev 37 (9 Pt A): 2047–2058.
Tang DW, Fellows LK, Small DM, Dagher A (2012). Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies. Physiol Behav 106: 317–324.
Wolf ME (2016). Synaptic mechanisms underlying persistent cocaine craving. Nat Rev Neurosci 17: 351–365.
About this article
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