Figure 4

From: Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

Figure 4

Effect of URB597 or URB694 on relapse to nicotine seeking in abstinent squirrel monkeys. (a, b) During extinction, vehicle was substituted for nicotine. Treatment with URB597 (a) or URB694 (b; both 1 mg/kg IV, 30 min before the session) blocked the reinstatement of extinguished nicotine-seeking responses produced by a nicotine-priming injection (0.1 mg/kg IV, immediately before the session), and this effect was prevented by pretreatment with MK886 (1 mg/kg IM, 45 min before the session). **P<0.01, post hoc vs ‘vehicles+vehicle priming’; ##p<0.01, post hoc vs ‘vehicles+nicotine priming’, $$p<0.01, post hoc vs ‘URB 1+nicotine priming’, Tukey’s test. (c, d) During extinction, injection-paired visual cues and response-contingent IV nicotine injections were removed. Treatment (the same as in a and b) with URB597 (c) or URB694 (d) blocked the reinstatement of extinguished nicotine-seeking responses induced by reintroduction of visual cues and IV saline injections. The effect of URB694, but not URB597, was partially reversed by pretreatment with MK886. *P<0.05, **p<0.01, post hoc vs ‘vehicles+no cues’; ##p<0.01, post hoc vs ‘vehicles+cues’, $$p<0.01, post hoc vs ‘URB 1+cues’, Tukey’s test. Total numbers of lever presses produced per 1 h session are shown (a–d). Each bar represents mean±SEM (n=4). ‘0 mg/kg’ represents vehicle in all panels.