Figure 2

From: Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

Figure 2

Effect of URB597 or URB694 on nicotine self-administration in squirrel monkeys under a fixed-ratio 10 (FR10) schedule. (a–f) Pretreatment with URB597 or URB694 (both 1 mg/kg IV, 30 min before the session) caused significant (all p’s <0.01) rightward shifts of the nicotine dose–response curves compared with vehicle (V) pretreatment. Number of nicotine injections per 1-h session (a, d), overall response rates in the presence of the green light signaling nicotine availability (b, e), and total nicotine intake per session (c, f) are shown as a function of the nicotine dose (abscissae log scale). Each data point represents the mean±SEM of the last three sessions under each nicotine condition and under vehicle conditions (n=4). *P<0.05, **p<0.01, post hoc comparisons of the effects of pretreatment with URBs vs vehicle treatment within each nicotine dose, Tukey’s test.