Figure 1

From: Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse

Figure 1

Effect of URB597 or URB694 administration on FAAH activity and levels of FAEs in the brain of monkeys. (a, b) Inhibition of brain (a, cerebellum) and liver (b) FAAH activity 1 h after URB597, URB694 (both 1 mg/kg), or vehicle IV administration. (c–f) Midbrain concentrations of anandamide (c; AEA), 2-arachidonoylglycerol (d; 2-AG), PEA (e), and OEA (f) 1 h after vehicle, URB597, or URB694 (both 1 mg/kg) IV administration. Results are expressed as means±SEM (n=4–6). ***P<0.001 post hoc comparisons with vehicle (VEH) conditions, Tukey’s test.