Table 1 Clusters of Brain Regions That Were Activated During the CO2 Pain Stimulus (Main Effect ‘Stimulus’ in a 2 × 2 Factorial Design, Contrast 1 1 1 1 in the Succession Placebo Baseline Session, Placebo Post-Drug Session and THC Baseline Session, THC Post-Drug Session, Resp.)

From: Brain Mapping-Based Model of Δ9-Tetrahydrocannabinol Effects on Connectivity in the Pain Matrix

Brain regions within cluster MNI coordinates t -values of peak coordinates
  x y z  
Right rolandic operculum/insula/superior temporal gyrus 57 −4 10 10.73
Right anterior and median cingulate gyri/supplementary motor area 12 −16 37 9.35
Right calcarine fissure/left calcarine fissure/left cuneus 15 −73 7 8.03
Right postcentral gyrus 27 −28 52 7.74
Right cerebellum 18 −64 −26 6.86
Left cerebellum −12 −64 −26 6.75
Left inferior frontal gyrus −36 8 16 6.63
Right superior occipital gyrus 18 −82 28 6.58
Right thalamusa 15 −10 4 8.64
  1. Results reflect a 14-subject analysis. Voxels are given at a threshold of p<0.05 (FWE-corrected, cluster size threshold 5 voxels). Coordinates are reported in MNI space (mm).
  2. aActivity when applying an anatomical mask of the bilateral thalamus to identify region of interest (ROI) for connectivity analyses.