Figure 5

From: Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects

Figure 5

Ketamine prevents effects of OF on PA learning and formation of silent synapses (a) Timeline of experiment (left). Latency to enter dark compartment during PA training and testing in mice injected with saline (middle) or ketamine (right) immediately after OF. (b) AMPAR/NMDAR index (left), AMPAR/NMDAR ratio (left middle), the ratio of CV-NMDAR/CV-AMPAR (right middle) and estimated fraction of silent synapses (right). Data from Figures 2 and 4 are included for comparison. White, black, gradient and gray represent, respectively, control, OF, ketamine-injected controls, and ketamine-injected OF mice. Data are presented as mean±SEM. Number of cells (upper) and animals (lower) are shown. *p<0.05, **p<0.01.