Figure 1

From: Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects

Figure 1

OF enhances PA learning and recruits dmPFC and BLA (a) Experiment timeline. (b) OF chamber. (c) Latencies to enter dark compartment during PA training and testing. (d and e) Representative c-Fos immunostaining of dmPFC (d) and BLA (e) slices from control and OF mice. Insets show magnified images of quantified areas. (f) Summary counts of c-Fos-positive cells per mm2. White and black represent, respectively, control and OF. Data are presented as mean±SEM. Number of animals are shown in parentheses. *p<0.05. BLA, basolateral amygdala; dmPFC, dorsomedial prefrontal cortex; OF, observational fear; PA, passive avoidance.