Figure 4

From: Beer Flavor Provokes Striatal Dopamine Release in Male Drinkers: Mediation by Family History of Alcoholism

Figure 4

(a) Statistical map in the sagittal and (b) coronal views illustrating the location of increased striatal DA response in FHP (FHP>FHN). Voxel-wise display threshold, p<0.01, uncorrected. (c) For illustration, mean (±SEM) values were extracted using all voxels with ΔBPND>0 in the full n=49 sample (voxel-wise P<0.01, uncorrected) that were within the anatomically defined right ventral striatum. ΔBPND values (mean±SEM) in the right ventral striatum indicate that subjects with first-degree relatives with probable alcoholism (FHP, n=12) exhibited larger relative increase in ΔBPND (eg, higher DA levels during the beer condition) compared with both family history ambiguous (FHA: second degree alcoholic relatives only, n=18) and family history negative (FHN: no alcoholic relatives, n=19). AUD, alcohol use disorder; BP, binding potential; DA, dopamine.