Figure 1

From: Cannabinoids Ameliorate Impairments Induced by Chronic Stress to Synaptic Plasticity and Short-Term Memory

Figure 1

The effects of chronic exposure to restraint stress and WIN55,212-2 on synaptic plasticity in the ventral subiculum-nucleus accumbens pathway. (a) The Stress-Vehicle group demonstrates reduced amplitude levels compared with the Stress-WIN and No Stress-Vehicle groups (**p<0.01). (b) The Stress-Vehicle group demonstrates reduced slope levels compared with the Stress-WIN and No Stress-Vehicle groups (#p=0.053, **p<0.01). (c) Representative traces in the NAc taken before (black) and 1 hr after (gray) HFS to the vSub (calibration: 0.2 mV, 10 ms). Up: the Stress-Vehicle group; Down: the Stress-WIN group. (d) The Stress-Vehicle group demonstrates reduced amplitude levels compared with the Stress-WIN and No Stress-Vehicle groups (*p<0.05; **p<0.01). (e) The Stress-Vehicle group demonstrates reduced slope levels compared with the No Stress-Vehicle and Stress-WIN groups, and the Stress-AM+WIN group demonstrates reduced slope levels compared with the No Stress-Vehicle group (#p=0.055; *p<0.05; **p<0.01).