Figure 2

From: Functional Status of the Serotonin 5-HT2C Receptor (5-HT2CR) Drives Interlocked Phenotypes that Precipitate Relapse-Like Behaviors in Cocaine Dependence

Figure 2

Inherent impulsive action predicts cocaine cue reactivity. Following phenotype identification, the one-choice serial reaction time (1-CSRT) task sessions were terminated, and HI rats and LI rats were retained in their home cages and allowed to free-feed for 7 days before surgical implantation of a jugular catheter. (a) In daily 180 min sessions, HI and LI rats readily acquired cocaine self-administration (0.75 mg/kg/0.1 ml infusion) to stability. (b) On forced abstinence (FA) day 14, HI rats exhibited a higher number of previously active (*p<0.05 vs LI), but not inactive lever presses (n.s.), during the cue reactivity test session vs LI rats. (c) There was a positive correlation between premature responses on the 1-CSRT task and cue-reinforced lever presses during the cue reactivity test session for individual subjects (r=0.502; p<0.05).