Figure 8

From: In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor Activity

Figure 8

Effects of 10 mg/kg MDPV (black circles) or MDMA (white diamonds) on thermoregulation when administered in either a cool (left panel) or warm (right panel) ambient environment. The ‘X’ adjacent to the last data point obtained following administration of MDMA in the warm ambient environment denotes the approximate time that all mice were removed from the chambers and euthanized, in accordance with our IACUC protocol. Shaded regions represent the range of core temperatures recorded over 24 h from mice treated with saline. Abscissae: points to the left of the up arrow denote baseline data prior to injection. Numbers refer to time, in minutes, following MDPV or MDMA administration. Ordinates: core temperature, in °C, as measured by radiotelemetry.