Figure 4

From: In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor Activity

Figure 4

Left panel—locomotor activity elicited by administration of saline (squares) or various doses of MDPV (circles) in a cool (filled) or warm (unfilled) ambient environment. Abscissa: ‘SAL’ represents saline control data at both ambient temperatures. Numbers refer to doses of MDPV, in separate groups of animals, expressed as mg/kg on a log scale. Ordinate: mean total activity recorded over 6 h post injection, via radiotelemetry. The ‘(4)’ adjacent to the data point for 30 mg/kg MDPV administered in the warm ambient environment denotes that four (of six) mice were killed at various time points after injection when self-injurious behavior was observed. Asterisks indicate significant differences between doses administered at ambient temperatures of 20 and 28°C. Right panel—time course of locomotor stimulation following administration of 10 mg/kg MDPV in a cool (black circles) or warm (white circles) ambient environment. Abscissa: points to the left of the up arrow denote baseline data before injection, presented as the mean activity observed over 1 h. Numbers refer to time, in minutes, following MDPV administration. Ordinate: mean activity counts calculated in 30 min bins.