Figure 3

From: Candesartan, an Angiotensin II AT1-Receptor Blocker and PPAR-γ Agonist, Reduces Lesion Volume and Improves Motor and Memory Function After Traumatic Brain Injury in Mice

Figure 3

Changes in the CBF and blood pressure after CCI injury in mice treated with vehicle or candesartan. Mice were administered candesartan or vehicle by daily injection for 3 days, starting 5 h before injury. (a) Regional CBF (rCBF) was measured before injury, during, 2 and 18 h after injury, and was expressed as % baseline values (arbitrary units) in the ipsilateral hemisphere. At 2 and 18 h post-injury, candesartan treatment increased CBF values compared with vehicle. (mean±SEM, n=12–17, *p<0.05, ***p<0.001). (b) Blood pressure (BP) in CCI mice with vehicle (CCI-VH) or candesartan-treated (CCI-CD) measured before, and 2 and 24 h after injury, (mean±SEM, n=6).