Figure 2 | Neuropsychopharmacology

Figure 2

From: A Cannabinoid CB1 Receptor Antagonist Ameliorates Impairment of Recognition Memory on Withdrawal from MDMA (Ecstasy)

Figure 2

Effect of a cannabinoid CB1 receptor antagonist, AM251, on cognitive impairment on the 7th day of MDMA withdrawal (10 mg/kg, i.p., daily for 7 days) in wild-type mice. (a) AM251 (1.0 or 3.2 mg/kg, i.p.) was co-administered with MDMA. Data represent the mean±SEM (n=8–15). ***p<0.001 vs vehicle-treated mice; ###p<0.001 vs MDMA (10 mg/kg)-treated mice. Vehicle means results for mice administered saline. (b) AM251 (1.0 or 3.2 mg/kg, i.p.) was administered 30 min before the training trial. Data represent the mean±SEM (n=5–15). ***p<0.001 vs vehicle-treated mice; ###p<0.001 vs MDMA-treated mice. Vehicle means results for mice administered saline.

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