Abstract
The authors' goal was to screen for genetic linkage with highly informative deoxyribonucleic acid (DNA) microsatellite markers on a series of moderately sized North American bipolar disorder (BP) pedigrees. These BP pedigrees were genotyped with 57 short tandem–repeat polymorphic systems (microsatellites) that were enzymatically amplified from genomic DNA. We did not find significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.
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Gejman, P., Martinez, M., Cao, Q. et al. Linkage Analysis of Fifty-Seven Microsatellite Loci to Bipolar Disorder. Neuropsychopharmacol 9, 31–40 (1993). https://doi.org/10.1038/npp.1993.40
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DOI: https://doi.org/10.1038/npp.1993.40
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