Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Secondary metabolism: High cholesterol in tomato

A straightforward approach reveals the full cholesterol biosynthetic pathway in tomato, which is composed of ten enzymatic steps, opening the door for bioengineering of high-value molecules in crops. Phylogenetic analysis suggests that cholesterogenesis evolved from the more ancient phytosterol pathway.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A simplified scheme of the sterol pathway in plants.

References

  1. 1

    Dutta, P. C. (ed.) Phytosterols as Functional Food Components and Nutraceuticals (Marcel Dekker, 2004).

    Google Scholar 

  2. 2

    Benveniste, P. Annu. Rev. Plant Biol. 55, 429–457 (2005).

    Article  Google Scholar 

  3. 3

    Garg, V. K., Douglas, T. J. & Paleg, L. G. in The Metabolism, Structure and Function of Plant Lipids (eds Stumpf, P. K., Mudd, J. B. & Nes, W. D. ) 83–85 (Plenum Press, 1986).

    Google Scholar 

  4. 4

    Noda, M., Tanaka, M., Seto, Y., Aiba, T. & Oku, C. Lipids 23, 439–444 (1988).

    CAS  Article  Google Scholar 

  5. 5

    Kreis, W. & Müller-Uri, F. in Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches (eds Bach, T. J. & Rohmer, M. ) 425–438 (Springer, 2013).

    Google Scholar 

  6. 6

    Svoboda, J. A. in Biochemistry and Function of Sterols (eds Parish, E. J. & Nes, W. D. ) 55–63 (CRC Press, 1997).

    Google Scholar 

  7. 7

    Sonawane, P. D. et al. Nat. Plants 2, 16205 (2017).

    Article  Google Scholar 

  8. 8

    Nes, W. D. Chem. Rev. 111, 6423–6451 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Oehlschlager, A. C., Angus, R. H., Pierce, A. M., Pierce, H. D. & Srinivasan, R. Biochemistry 23, 3582–3589 (1984).

    CAS  Article  Google Scholar 

  10. 10

    Mo, C. & Bard, M. Biochim. Biophys. Acta 1737, 152–160 (2005).

    CAS  Article  Google Scholar 

  11. 11

    Sawai, S. et al. Plant Cell 26, 3763–3774 (2014).

    CAS  Article  Google Scholar 

  12. 12

    Suzuki, M. et al. Plant Cell Physiol. 47 565–571 (2006).

    CAS  Article  Google Scholar 

  13. 13

    Lodeiro, S., Schulz-Gasch, T. & Matsuda, S. P. T. J. Am. Chem. Soc. 127, 14132–14133 (2005).

    CAS  Article  Google Scholar 

  14. 14

    Nemethy, E. K., Skrukud, C., Piazza, G. J. & Calvin, M. Biochim. Biophys. Acta 760, 343–349 (1983).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Thomas J. Bach.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bach, T. Secondary metabolism: High cholesterol in tomato. Nature Plants 3, 16213 (2017). https://doi.org/10.1038/nplants.2016.213

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing