The auxin receptor TIR1 is an F-box protein functioning in a ubiquitin ligase complex to target repressors for degradation. It is itself an unstable protein, but newly identified mutations protect both TIR1 and its substrates from degradation. These mutations could help in identifying the substrates for hundreds of other F-box proteins.
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References
Yu, H. et al. Nature Plants 1, 14030 (2015).
Gagne, J. M., Downes, B. P., Shiu, S. H., Durski, A. M. & Vierstra, R. D. Proc. Natl Acad. Sci. USA 99, 11519–11524 (2002).
Vierstra, R. D. Nature Rev. Mol. Cell Biol. 10, 385–397 (2009).
de Saint Germain, A., Bonhomme, S., Boyer, F. D. & Rameau, C. Curr. Opin. Plant Biol. 16, 583–589 (2013).
Calderon Villalobos, L. I. et al. Nature Chem. Biol. 8, 477–485 (2012).
Stuttmann, J. et al. J. Biol. Chem. 284, 7920–7930 (2009).
Parry, G. et al. Proc. Natl Acad. Sci. USA 106, 22540–22545 (2009).
Dharmasiri, N. et al. Dev. Cell 9, 109–119 (2005).
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Weijers, D. Auxin: Harnessing a loose cannon. Nature Plants 1, 15024 (2015). https://doi.org/10.1038/nplants.2015.24
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DOI: https://doi.org/10.1038/nplants.2015.24
