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Asthma control and management in 8,000 European patients: the REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey



Asthma is one of the most common chronic diseases in the world, and previous studies have reported low levels of control. Recent developments in the availability and use of online sources of information about asthma might add to patients’ knowledge and help improve control.


To investigate whether asthma control has improved by assessing levels of symptoms, exacerbations and Global Initiative for Asthma-defined control in a real-life population of patients who use the Internet and social media, as well as evaluate patient perception of control and attitudes to asthma.


Online surveys were conducted among 8,000 patients with asthma (aged 18–50 years, 2 prescriptions in the previous 2 years, use of social media) from 11 European countries.


Levels of asthma control were low: 45% of respondents had uncontrolled asthma. Acute exacerbations were common: 44% of respondents reported having used oral steroids for asthma in the previous 12 months, 24% had visited an emergency department and 12% had been hospitalised. More than 80% of respondents (overall, and among those with a history of exacerbations) considered their asthma to be controlled. Of those who had an exacerbation requiring oral steroids, 75% regarded their asthma as not serious.


Asthma control in Europe remains poor; symptoms and exacerbations are common. Many patients regard their asthma as controlled and not serious despite experiencing symptoms and exacerbations. There is a need to assess patients’ control, risk and inhaler technique, and to ensure that patients are prescribed, and take, appropriate treatments.


Asthma is one of the most common chronic conditions in the world; according to the Global Burden of Disease Study, asthma caused more than 345,000 deaths worldwide in 2010.1,2 In Europe alone, asthma affects 30 million people,2,3 and the cost of asthma care in Europe is estimated at £18 billion per year; lost productivity accounts for almost £10 billion of this.3,4

Asthma control in clinical practice is suboptimal despite available therapies;57 over the last decade, European studies have shown little apparent improvement in the levels of symptom control.5,7 Poor asthma control is associated with increased risk of exacerbations, debilitation, impaired quality of life, increased health-care utilisation and reduced productivity.5,7,8 Asthma can remain uncontrolled in patients prescribed regular therapy, who may continue to experience exacerbations.7 Importantly, a history of asthma exacerbations is a risk factor for future exacerbations; hence, understanding predictive factors is important.9 Other risk factors include poor asthma control and poor adherence.9,10

International guidelines, such as those produced by the Global Initiative for Asthma (GINA), state that treatment should be based on a patient’s level of asthma control defined by daytime symptoms, normal activities affected by symptoms, night-time awakenings and reliever inhaler use.2 The incidence of asthma control in clinical practice is considerably lower than the levels (up to 70%) reported in many randomised controlled trials.1113 This may be because randomised controlled trials are not representative of real life, because only a very small subset of patients from clinical practice (1–2%) is eligible for inclusion,14 or because trial participation influences participants’ behaviour (the ‘Hawthorne effect’).15

Many patients may overestimate their symptom control and underestimate the severity of their condition, indicating that they tolerate symptoms and lifestyle limitations.7,16 Patients may describe symptoms more positively to their health-care professionals (HCPs) than they would when completing a validated questionnaire. To develop effective asthma therapies and to improve real-life outcomes, it is therefore important to understand, and adapt to, different patients’ attitudes towards their condition and to tailor treatments to their specific needs.2 This requires effective communication, a valid assessment of control, a clear understanding between patients and HCPs, and greater patient knowledge about their condition.

Here, we report data from the REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey, conducted in 11 European countries among 8,000 individuals who use social media—the largest and most recent survey of its kind.5,1620 This survey assessed symptoms and levels of asthma control in a real-life setting and evaluated how symptoms and indicators of acute exacerbations relate to guideline-defined control and different treatment levels; in addition, current asthma control was analysed in relation to exacerbation history. Patients’ perceptions of asthma control and symptoms were also explored. The data provide important new insights into patients’ attitudes and whether real-life asthma control has improved in recent years.

Materials and Methods

Survey design

This quantitative, questionnaire-based survey was designed to:

  • assess symptoms, indicators of acute exacerbations and levels of guideline-defined control in a real-life population of patients who use social media;

  • compare asthma symptoms, exacerbations and control levels across different treatment levels (reliever inhaler only, single-drug preventer inhaler, combination preventer inhaler and combination preventer inhaler plus oral pill);

  • report the incidence of past exacerbations stratified by current asthma control level;

  • investigate respondents’ perceptions of asthma control in relation to their guideline-defined level of control and history of exacerbations; and

  • explore attitudes of patients towards asthma and its management, and investigate the sources of information preferred by patients who use social media.

The survey was conducted online in 11 European countries (Austria, Belgium, Finland, France, Germany, Italy, the Netherlands, Norway, Spain, Sweden and the United Kingdom), between July and October 2012, by Incite Marketing Planning Limited (London, UK), in accordance with the Codes of Conduct of the Market Research Society, European Pharmaceutical Marketing Research Association and Association of the British Pharmaceutical Industry, and guidelines from the British Healthcare Business Intelligence Association. Data were managed in accordance with the Data Protection Act (UK, 1998). The survey was supported by Mundipharma International Limited (Cambridge, UK).

Questionnaire development

The questionnaire was developed through a series of meetings with experts in the field and the authors, who provided input and advice on the questions, methodology and structure of the survey. A cognitive testing phase was conducted in Germany with six participants to ensure that questions were unambiguous and to test the validity and consistency of responses; minor amendments were made to clarify the questions. Questionnaires took approximately 30 min to complete.

Survey population

This survey was conducted among individuals aged 18–50 years who confirmed that they had been diagnosed with asthma by a doctor, had at least two prescriptions for asthma in the previous 2 years and used social media. Respondents who had participated in market research surveys within the previous 3 months were excluded.

The survey population was drawn from validated consumer panels, which were mainly recruited online (Watermelon Research, London, UK). In Norway and Finland, recruitment was supplemented by press advertising. Approximately 590,740 members of the general public (regardless of asthma status) who had previously registered on consumer panels and had agreed to take part in market research were sent an e-mail inviting them to participate. The invitation described the survey as ‘health related’, but did not mention asthma. Those who clicked the link to start the questionnaire were asked screening questions to ensure that they had asthma and met the other inclusion criteria (Figure 1); eligible participants were then able to complete the full questionnaire. Upon completion of the survey, respondents immediately received a reward in a points-based incentive scheme. Of the 88,611 individuals who responded, the first 38,894 were excluded as soon as they failed a screening question; the process was subsequently amended to streamline recruitment and enrolment, and all other respondents (n=49,717) answered all screening questions before being excluded; this technical amendment did not affect the outcome of the screening. The target survey population was 8,000; this sample size was chosen to provide a sufficiently large and robust population across the different countries. Additional respondents were not recruited once this number was achieved.

Figure 1

Survey design. aParticipants were excluded if they failed one or more screening questions (see Methods). bData shown for individual answers to screening questions; 49,717 respondents answered all screening questions before being screened and hence the total number of reasons for exclusion exceeds 69,646.

Panels met the International Organization for Standardization 20252 quality standards; multiple panels were used to reduce potential bias. Quality control measures (including cross-referencing of Internet addresses) identified respondents registered on multiple panels; these respondents were excluded.

Data analysis

Questionnaire responses were analysed for the total population; answers relating to indicators of acute exacerbations and symptoms were analysed by asthma control level and treatment type. Asthma control was assessed using the four GINA criteria based on the questions from the Helping Asthma in Real-life Patients initiative, which asked on how many days in the previous 7 days respondents had day-time symptoms, had awoken at night or had their normal activities affected by asthma, and how many times they had used a reliever inhaler.21 Respondents’ perceptions of asthma were analysed by GINA-defined control level and exacerbations. Respondents were asked which treatments they were currently taking: ‘reliever/rescue inhaler’, ‘preventer inhaler’, ‘combination inhaler’, ‘oral treatment (pill)’ or ‘other asthma medication’.

The relationship between indicators of asthma symptoms and exacerbations and GINA-defined control was assessed using Pearson’s correlation coefficient (r). Correlations of r0.6 were considered strong.


Respondent population

Of the 590,740 individuals invited to participate, 88,611 started answering the questionnaire (response rate 15.0%); this response rate is broadly consistent with those for previous surveys. In total, 69,646 respondents did not meet the inclusion criteria and were excluded; the most common reason was not having asthma (98.3% (n=68,479); Figure 1). After data quality checks, 8,000 respondents were included in the final survey and data analysis and constituted the survey population (Table 1).

Table 1 Respondent demographics and characteristics

Asthma control and symptoms

Overall, 20.1% of respondents had controlled asthma according to the GINA criteria, 34.8% had partially controlled asthma and 45.1% had uncontrolled asthma (Table 2). Over half of the respondents had awoken at night or had symptoms that interfered with daily activities in the week before completing the survey. Overall, 44.0% of respondents reported having used oral steroids for asthma in the previous 12 months, 23.9% reported having visited an emergency department and 11.7% reported having been hospitalised overnight. Breathlessness was identified as the symptom with the greatest impact (Figure 2).

Table 2 Indicators of asthma symptoms and exacerbations overall and by GINA-defined control levels
Figure 2

Asthma symptoms with the greatest impact on respondents’ lives for the overall population. Q. Which asthma symptoms do you find affect you most? Place in order, with 1 having the most impact on your life and 5 the least. Base: N=8,000. Numbers shown are percentages.

Symptoms and exacerbations across control levels

Incidences of asthma symptoms and indicators of exacerbations across asthma control levels are shown in Table 2. Some respondents whose asthma was currently controlled according to the GINA criteria reported a history of acute exacerbations in the previous year: 42.3% used antibiotics, 23.7% required oral steroids, 7.4% visited an emergency department and 1.6% had been hospitalised overnight owing to asthma in the 12 months before the survey.

Symptoms and indicators of acute exacerbations across treatment levels

Table 3 presents GINA-defined levels of asthma control, incidence of symptoms and indicators of acute exacerbations stratified by treatment level. Symptoms tended to be more common among respondents prescribed maintenance therapy than among those prescribed only a reliever inhaler (Table 3). The proportion reporting indicators of acute exacerbations increased consistently with treatment level. Notably, across all treatment levels, half of the respondents had been prescribed a course of antibiotics owing to their asthma and more than one-quarter had required oral steroids in the previous 12 months. High levels of reliever inhaler use (10 times in the previous 7 days) were most common among respondents prescribed a combination preventer inhaler.

Table 3 Asthma control and indicators of symptoms and exacerbations by treatment level

Respondents’ perceptions of asthma

Respondents’ perceptions of their asthma symptoms and control are summarised in Table 4. Most did not regard themselves as ‘sick’, and many stated that they ignored their asthma to ‘feel normal and fit in’. More than 80% of respondents considered their asthma to be controlled and over two-thirds did not regard their condition as serious, even among those whose asthma was uncontrolled according to the GINA criteria (Table 5). Similarly, more than 80% of respondents who had experienced acute exacerbations (oral steroid use, emergency department visits or hospitalisations) in the previous year regarded their asthma as controlled. Of those who considered their asthma controlled, 55.5% had had symptoms that interfered with normal activities and 52.5% had awoken at night owing to asthma in the previous week. Moreover, of those who regarded their asthma as not serious, 19.5% reported an asthma-related emergency department visit in the previous year.

Table 4 Patients’ perceptions of their asthma
Table 5 Patients’ perceptions of asthma control for the overall population and by GINA-defined control levels and exacerbations

Attitudes towards asthma and its management

The majority of respondents were fairly or very confident about managing their asthma (91.7%) and felt they had ‘excellent’ or ‘good’ knowledge about its treatment (75.3%). Over half of any respondents who stated that they had a preventer inhaler did not use it every day as prescribed (Figure 3). The most common reasons selected for non-adherence (base, n=1,401) were not seeing the need to take it (50.0%) or forgetting (18.6%). More than one-quarter of respondents felt embarrassed about their inhaler, and two out of five considered it a nuisance (Figure 4). Overall, 52.7% of respondents had not had their inhaler technique checked by an HCP in the previous 12 months.

Figure 3

Daily use of preventer medication. Q: Which statement best describes how you take your regular asthma treatment? This is your preventer inhaler, which is usually brown, orange or red. Base: respondents taking a preventer inhaler (overall: n=3,481; Global Initiative for Asthma-defined controlled: n=620; partially controlled: n=1,171; uncontrolled: n=1,690).

Figure 4

Respondents’ attitudes towards their inhaler. Q: To what extent do you agree with the following statements? Data shown for strongly agree plus tend to agree. Base overall: n=8,000; Global Initiative for Asthma-defined controlled: n=1,604; partially controlled: n=2,785; uncontrolled: n=3,611.

Sources of asthma information

Overall, 78.5% of respondents stated that they would consult their HCP for information about asthma (Figure 5); moreover, 60.7% said they would also use online sources—including search engines (43.6%), specific disease- or health-related websites (30.0%) and social media such as Facebook (4.1%) and Twitter (1.5%).

Figure 5

Sources of information about asthma. Q: If you were to look for information about asthma, which of the following would you use? Combined=all respondents who selected at least one answer from the list of possible options. Base: N=8,000.


Main findings

Overall, these data from the REALISE survey indicate that the level of GINA-defined asthma control remains low, with only one-fifth of respondents having controlled asthma. The incidence of symptoms and acute exacerbations was high; almost half of the respondents reported that they had required oral steroids for asthma in the previous year and almost one-quarter had visited the emergency department. Indeed, many respondents whose asthma was controlled at the time of the survey according to the GINA criteria reported a history of acute exacerbations over the previous year. Most respondents did not recognise symptoms as indicators of poor control, suggesting a continuing disconnection between patients’ perceptions of control and guideline-defined control.

Strengths and limitations of this study

The REALISE survey is one of the largest surveys of patients’ attitudes to asthma and its management in Europe to date, conducted in a population using the Internet and social media. As for any survey of this kind, however, there are some limitations. The main aim of REALISE was to provide a broad view of asthma control and patient attitudes across Europe as a whole. All data were analysed for the whole study population; however, there was some country-specific variation among respondents from the different countries included.22 All data were reported by the respondents and could not be clinically verified, and inaccurate responses due to poor recall cannot be excluded. This survey assessed patients aged 18–50 years who used social media, and this group may not be fully representative of the wider patient population. This study was not designed to compare asthma control among respondents who use social media with those who do not; it might be interesting to observe any effect of social media on asthma management in future surveys. The mean age of respondents is lower than that of patients with asthma in previous European appraisals in clinical practice, such as the European National Health and Wellness Survey.5,23 We believe, however, that the REALISE respondent population is broadly consistent with asthma populations reported in other studies. The proportion of females was comparable to those reported elsewhere (including the European Community Respiratory Health Survey and Asthma Insights and Reality in Europe),5,19,23,24 as were the proportions of current smokers and respondents prescribed controller medication.5,23 Moreover, the reported incidences of emergency department visits and hospitalisations due to asthma were similar to those in the National Health and Wellness Survey.5 Co-morbidities were self-reported by respondents and not clinically verified. We sought to compare the levels of co-morbidities with other, comparable survey populations, but these were frequently not reported.5,1719,22 Overall, the level of self-reported co-morbidities was relatively high, especially for a young population. Depression was the most frequent co-morbidity among REALISE respondents (prevalence, 13.5%), although this was observed to a greater degree in the Health and Wellbeing Study (21–29%).5 In the present survey, respondents were recruited from different consumer panels and, in some cases, through press advertising; however, this is unlikely to have introduced systematic bias.

Interpretation of findings in relation to previously published work

Overall, the findings of REALISE are in agreement with previous initiatives. Our present survey offers the largest pan-European appraisal of GINA-defined control, incidence of symptoms and exacerbations, and insights into patient attitudes and understanding of the disease (Table 6). The observed incidences of uncontrolled asthma and symptoms are broadly consistent with those reported in previous surveys of patients with asthma,7,1620,25 underlining the validity of this study. In a recent European survey, 54% of patients had asthma that was not well controlled,5 compared with 45% of respondents with uncontrolled asthma in the present survey. In the 2005 International Asthma Patient Insight Research survey, conducted in a population using combination therapy, the rate of uncontrolled asthma was 51%.7 Notably, in the current survey, the proportion of patients in the corresponding subset (those prescribed a combination preventer inhaler) with uncontrolled asthma was lower (41%), suggesting that, although asthma control remains low overall, there may have been a slight improvement in recent years.7 Patients using the Internet may benefit from access to online information sources about asthma. Interestingly, a study has shown that asthma control may be improved by online self-management strategies—including the monitoring of control, treatment advice and online education.26

Table 6 Other European surveys and studies of patients with asthma

Implications for future research, policy and practice

Frequent reliever inhaler use was notable; more than 40% of respondents had used their reliever three or more times in the previous week, and frequent use (10 times in the previous week) was highest in those prescribed a combination preventer inhaler. This may reflect high levels of uncontrolled asthma, but could also indicate an over-reliance on rescue medication, suggesting that patients do not recognise reliever use as a sign of deteriorating asthma and that their medication may require adjustment.7

Our survey also found a high incidence of oral steroid use, emergency department visits and hospitalisations over the 12 months before the survey, even among those whose asthma was controlled at the time of the survey. These indicators are consistent with the American Thoracic Society/European Respiratory Society Statement definition of severe exacerbations in clinical trials,27 demonstrating that exacerbations in clinical practice remain common and are a serious concern. Currently controlled asthma does not preclude future exacerbations. Accordingly, in addition to a patient’s current level of symptoms and asthma control, it is important to assess their exacerbation risk.9 Indeed, international guidelines state that the joint aims of asthma management should be to achieve asthma control and reduce exacerbation risk. Our findings may suggest a need to improve the assessment of control and patients’ risk for future exacerbations.

GINA guidelines recommend a stepwise approach to asthma management.2 The proportion of respondents with uncontrolled asthma was high across all treatment levels, which may indicate under-use, inappropriate use or under-prescription of therapies; this highlights the need for HCPs to supervise treatment use more closely, provide hands-on advice and guidance, and empower patients through education to achieve better self-management of their asthma.

The data also provide insights into patient attitudes to asthma and its treatment. Most respondents did not want to be labelled as sick; the majority also regarded their asthma as controlled and not serious, even among respondents with uncontrolled asthma, highlighting a disconnection between patients’ perceptions of their asthma and guideline-defined levels of control. This disconnect has been reported before, and it is worrying that there has been little apparent improvement;6,19,20,28 in a previous survey, up to half of the patients with severe persistent symptoms considered their asthma to be controlled.6,19

These findings together show a need to ensure that asthma is accurately assessed in clinical practice, and to improve patients’ understanding so that symptoms and exacerbations are recognised and acted upon. The disconnection between patient-perceived and guideline-defined control may be partly due to different aspirations of patients and HCPs, as well as different definitions of ‘control’ between patients and variations in assessments from clinical questionnaires. For patients, asthma control may be most easily understood as managing exacerbation risk, rather than as achieving a predefined threshold of symptom control. In addition, successful asthma management requires a good partnership between patients and HCPs;28 a shared language and understanding is vital. Training HCPs in patient-centred communication skills can help optimise asthma management in primary care.29

In clinical practice, prescriptions are often initiated based on limited information gained from short conversations during consultations. However, asthma control should be assessed using standardised tools such as the Asthma Control Questionnaire or the Asthma Control Test, which can potentially improve the assessment of control in a reproducible, objective way.2

Non-adherence and poor inhaler technique are associated with suboptimal asthma control.3032 It is concerning that ~50% of respondents reported that they did not take their maintenance therapy as prescribed, and fewer than half had had their inhaler technique checked by an HCP in the previous year. Many patients frequently use their inhaler incorrectly;3335 however, training can improve control. In a recent study, the proportion of patients with optimal inhaler technique rose from 24 to 79% following training, leading to significant increases in asthma control scores.36 For effective instruction the trainer must also be competent in using the device;30 unfortunately, some HCPs are not aware of optimal inhaler technique.37

The Internet may support patient self-management of chronic conditions.26 Notably, over half of the respondents in the present survey stated that they would use online sources for information about their asthma; providing patients with access to reliable websites may thus increase their level of understanding and help improve asthma control.18,26

This report presents the first set of results from the REALISE survey. The large size of the population (which included 240–1,024 respondents from each country) and the diversity of the participating countries support further analyses, including assessment of variations in asthma control and treatment across the countries. The survey also gathered a large amount of novel information on patients’ attitudes to asthma. This could be used to analyse patients’ behaviour and attitudes to online sources for information about asthma; the data will be explored to determine whether different patient types exist and whether such information could help develop tailored asthma management strategies.


Asthma control in Europe remains poor, and symptoms and exacerbations are common across all treatment levels. Many patients with asthma do not regard themselves as sick and are not concerned about their condition, believing it to be controlled; many individuals do not associate symptoms with poor control. Hence, there remains a marked discrepancy between patient-perceived and guideline-defined asthma control. There is a clear need to assess patients’ control, risk and inhaler technique, and to ensure that they are prescribed, and take, appropriate treatments. Educating patients will help improve their understanding of asthma and enable them to work with their HCP to manage their disease.


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We thank Dr Peter Haidl (Schmallenberg, Germany) and Professor Chantal Raherison-Semjen (Bordeaux, France) for their advice and input on the survey questions. We are also grateful to Weber Shandwick (London, UK) for assistance in developing and running the survey, Incite Marketing Planning Ltd (London, UK) for support in the development of the questionnaire and analysing the results, and Dr Mark Rolfe and Dr Andreas Leidenroth (Oxford PharmaGenesis, Oxford, UK) for medical writing support.

Author information




All authors contributed to the conception and design of the survey, interpretation of the data, and development of the flow, outline and content of the manuscript; the authors reviewed each draft of the full manuscript and approved the final version. The authors take full responsibility for the content of the article and act as guarantors.

Corresponding author

Correspondence to David Price.

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Competing interests

DP has acted as a consultant and board member for Almirral, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Meda Pharma, Merck, Mundipharma, Napp, Novartis, Nycomed, Pfizer, Sandoz and Teva. He or his research team has received grants and support for research in respiratory disease from the following organisations in the past 5 years: Aerocrine, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Merck, Mundipharma, Novartis, Nycomed, Orion, Pfizer, Teva and the UK National Health Service. Grants/grants pending: Aerocrine, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Merck, Mundipharma, Novartis, Nycomed, Orion, Pfizer, Takeda, Teva and the UK National Health Service. Payments for lectures/speaking: Activaero, Almirral, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, GlaxoSmithKline, Kyorin, Novartis, Merck, Mundipharma, Pfizer, Takeda and Teva. Payment for manuscript preparation: Merck, Mundipharma and Teva. Stock/stock options: shares in AKL Ltd, which produces phytopharmaceuticals; owner of 80% of Research in Real Life and its subsidiary social enterprise Optimum Patient Care. Payment for travel/accommodation/meeting expenses: Aerocrine, Boehringer Ingelheim, Mundipharma, Napp, Novartis and Teva. MF has received reimbursement for travel and accommodation from Amirall UK and Novartis AG. Education for Health received honoraria from Almirall, Boehringer, Ingelheim, Novartis AG and Novartis UK for advisory boards attended by MF. It also received educational grants from Almirall, Chiesi and TEVA, and grants for research in the last 5 years from Abbott Laboratories, AstraZeneca, Novartis AG, Pfizer and UCB. TvdM has acted as a consultant and board member for Almirral, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Mundipharma, Novartis and Teva, and as a consultant for MSD. Grants/grants pending: His research department at the University of Groningen has received grants and support for research in respiratory disease from the following organisations in the past 5 years: AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Lung Foundation Netherlands, Merck, Mundipharma, Novartis, Nycomed and Stichting Astma Bestrijding. Payments for lectures/speaking: Almirral, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, GlaxoSmithKline, Kyorin, Merck, Mundipharma, Novartis and Teva. Payment for travel/accommodation/meeting expenses: Boehringer Ingelheim, Mundipharma, Novartis and Teva.

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Price, D., Fletcher, M. & van der Molen, T. Asthma control and management in 8,000 European patients: the REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey. npj Prim Care Resp Med 24, 14009 (2014).

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