Figure 1 | npj Microgravity

Figure 1

From: Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella Typhimurium D23580

Figure 1

Survival of mice following peroral infection with D23580 grown in the Rotating Wall Vessel (RWV) under low fluid shear (LFS) or higher fluid shear (HFS). D23580 was cultured in the RWV under LFS or HFS to mid-to-late log phase in Lennox Broth (LB) media. Doses ranging from 102 to 109 colony-forming units (CFU) per mouse (five mice per dose) were administered to 8-week-old female BALB/c mice perorally. Mice were monitored three times a day for 30 days. An uninfected control group was included. (ac) The time to death of mice infected with 104, 105, or 106 CFU, respectively. Percent survival is defined as the percentage of mice surviving at the indicated number of days post infection. The median lethal dose (LD50) was determined by the method of Reed and Muench.12

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