Figure 3 | npj Genomic Medicine

Figure 3

From: Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care

Figure 3

EXaCT-1 reportable range. Number and percentage of common low coverage bases shared by 36 (80%) and all 45 (100%) control (germline) samples obtained from normal tissue. (a) The germline samples were expected to have low genomic complexity and therefore provide more accurate assessment of coverage and performance statistics. Over 95% of the HaloPlex exome bases were covered at >10×. (b) These guaranteed regions that have constant higher than 10× coverage is our reportable range, which is listed on our website (https://rubinlab.med.cornell.edu/IPMWES/Haloplex_Exome_Sequencing_reportable_region.xlsx). This poorly covered 4.29% genomic area of the HaloPlex exome will be excluded from our reportable range. The reportable range is listed on https://rubinlab.med.cornell.edu/IPMWES/HaloPlex_low_coverage_region.xlsx.

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