Table 1: Gene expression of cytokines and chemokines

From: Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

Name Functions in inflammation Ratio versus controla
    D1 D2 D3
CCL2 Chemokine, recruits monocytes 3.3 41 24
CXCL1 Cytokine, neutrophil chemoattractant 2.4 7.6 7.2
CXCL2 Cytokine, chemotactic to leukocytes 2.7 3.4 5.1
CXCL3 Cytokine, monocyte migration 1.8 4.2 6.0
IL-1-beta Cytokine, induces COX-2, inflammation 1.8 5.1 4.4
Interferon-gamma Cytokine, activates macrophages 1 1.2 7.2
TNF-alpha Cytokine, stimulates acute phase reaction 3.3 5.1 3.2
iNOS Inducible production of nitric oxide 1.1 2.4 8.6
TRL-6 Proinflammatory receptor 1 1.9 3.0
Fos Transcription factor 1.1 3.8 4.1
Jun Transcription factor 1.1 4.2 4.6
IL8 Chemokine, recruits neutrophils 5.0 35 58
IL8b Secreted protein ND 50b 139b
  1. a Days 1, 2, and 3 following the induction of Aβ synthesis in MC65 human nerve cells. Ratio of induced to uninduced. Done by Nano-String. Twelve of 184 genes assayed.
  2. b Secreted IL8 pg/ml/106 cells.