Figure 2

From: Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

Figure 2

Schematic representation and GC/MS/MS analysis of the induction of eicosanoid synthesis following Aβ expression in MC65 cells. Cells were induced to make Aβ (−tet) or not (+tet) for 48 h and the culture supernatant assayed for eicosanoids. Of the 164 eicosanoids assayed, these were the only ones detected. In the same experiment, induced cells were treated with 1 μmol/l THC, 10 μmol/l Calbiochem secretase inhibitor Ten (SI), or 500 nmol/l CNB-001. These data are from a single experiment, and similar results were obtained in three independent experiments. Although the absolute amounts of individual eicosanoids in the culture supernatants were somewhat variable, the relative effects of SI, THC and CNB-001 were the same. Aβ, beta amyloid.