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Misfits unite

The spontaneous assembly of particulate or molecular 'building blocks' into larger architectures underlies structure formation in many biological and synthetic materials. Shape frustration of ill-fitting blocks holds a surprising key to more regular assemblies.

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Figure 1: Models of self-assembly.


  1. Lenz, M. & Witten, T. M. Nat. Phys. 13, 1100–1104 (2017).

    Article  Google Scholar 

  2. Sadoc, J.-F. & Mosseri, R. Geometrical Frustration (Cambridge Univ. Press, 2006).

    Google Scholar 

  3. Tarjus, G., Kivelson, S. A., Nussinov, Z. & Viot, P. J. Phys. Condens. Matter 17, R1143–R1182 (2005).

    Article  ADS  Google Scholar 

  4. Grason, G. M. J. Chem. Phys. 145, 110901 (2016).

    Article  ADS  Google Scholar 

  5. Schneider, S. & Gompper, G. Europhys. Lett. 70, 136–142 (2005).

    Article  ADS  Google Scholar 

  6. Meng, G., Paulose, J., Nelson, D. R. & Manoharan, V. N. Science 343, 634–637 (2014).

    Article  ADS  Google Scholar 

  7. Zandi, R., Reguera, D., Bruinsma, R. F., Gelbart, W. M. & Rudnick, J. Proc. Natl Acad. Sci. USA 101, 15556–15560 (2004).

    Article  ADS  Google Scholar 

  8. Ghafouri, R. & Bruinsma, R. Phys. Rev. Lett. 94, 138101 (2005).

    Article  ADS  Google Scholar 

  9. Gibaud, T. et al. Nature 481, 348–351 (2012).

    Article  ADS  Google Scholar 

  10. Hall, D. M., Bruss, I. R., Barone, J. R. & Grason, G. M. Nat. Mater. 15, 727–732 (2016).

    Article  ADS  Google Scholar 

  11. Weisel, J. W., Nagaswami, C. & Makowski, L. Proc. Natl Acad. Sci. USA 84, 8991–8995 (1987).

    Article  ADS  Google Scholar 

  12. Makowski, L. & Magdoff-Fairchild, B. Science 234, 1228–1231 (1986).

    Article  ADS  Google Scholar 

  13. Chiti, F. & Dobson, C. M. Annu. Rev. Biochem. 75, 333–366 (2006).

    Article  Google Scholar 

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Correspondence to Gregory M. Grason.

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Grason, G. Misfits unite. Nature Phys 13, 1149–1150 (2017).

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