Review Article | Published:

Advances in real-time multispectral optoacoustic imaging and its applications

Nature Photonics volume 9, pages 219227 (2015) | Download Citation

Abstract

Optoacoustic imaging, or photoacoustic imaging, is insensitive to photon scattering within biological tissue and, unlike conventional optical imaging methods, makes high-resolution optical visualization deep within tissue possible. Recent advances in laser technology, detection strategies and inversion techniques have led to significant improvements in the capabilities of optoacoustic systems. A key empowering feature is the development of video-rate multispectral imaging in two and three dimensions, which offers fast, spectral differentiation of distinct photoabsorbing moieties. We review recent advances and capabilities in the technology and its corresponding emerging biological and clinical applications.

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Acknowledgements

We would like to thank Professor Simon Cherry (UC Davis), Mert Erkan and Stratis Tzoumas for useful discussions. A.T. acknowledges a Research Fellowship from the German Research Foundation (DFG). V.N. acknowledges funding from the DFG (SFB-824), the Gottfried Wilhelm Leibniz Prize of the DFG, and the European Commission project FAMOS (FP7 ICT).

Author information

Affiliations

  1. Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

    • Adrian Taruttis
  2. Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

    • Vasilis Ntziachristos
  3. Chair for Biological Imaging, Technische Universität München, Ismaninger Str. 22, Munich, Germany

    • Vasilis Ntziachristos

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Competing interests

V.N. is a founder of iThera Medical GmbH, a company that commercializes optoacoustic technology.

Corresponding author

Correspondence to Vasilis Ntziachristos.

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https://doi.org/10.1038/nphoton.2015.29

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