Super-resolution light microscopy methods either localize single molecular labels or treat the sample as a continuous object. The fundamental requirements for super-resolution in the continuum regime are spatially non-uniform illumination and a nonlinear photoresponse.
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Heintzmann, R., Gustafsson, M. Subdiffraction resolution in continuous samples. Nature Photon 3, 362–364 (2009). https://doi.org/10.1038/nphoton.2009.102
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DOI: https://doi.org/10.1038/nphoton.2009.102
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