Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Optical antennas focus in on biology

Biological processes often involve multimolecular interactions on a nanometre scale or at very large molecular concentrations, making them difficult to visualize. Optical antennas have the potential to become powerful tools for nanobioimaging by enhancing optical fields on this tiny scale.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Imaging a cell.
Figure 2: Potential applications of optical nanoantennas.

© 2003 NATURE REVIEWS MOLECULAR CELL BIOLOGY

References

  1. 1

    Grakoui, A. et al. Science 285, 221–227 (1999).

    Article  Google Scholar 

  2. 2

    Cambi, A. et al. J. Cell Bio. 164, 145–155 (2004).

    Article  Google Scholar 

  3. 3

    Schomburg, D. & Schomburg, I. Springer Handbook of Enzymes 2nd edn (Springer, New York, 2001).

    Google Scholar 

  4. 4

    Patel, S. S., Wong, I. & Johnson, K. A. Biochem. 30, 511 (1991).

    Article  Google Scholar 

  5. 5

    de Lange, F. et al. J. Cell Sci. 114, 4153–4160 (2001).

    Google Scholar 

  6. 6

    Ianoul, A. et al. Nature Chem. Biol. 1, 196–202 (2005).

    Article  Google Scholar 

  7. 7

    de Bakker, B. I. et al. ChemPhysChem 8, 1473–1480 (2007).

    Article  Google Scholar 

  8. 8

    de Bakker, B. I. et al. J. Cell Sci. 121, 627–633 (2008).

    Article  Google Scholar 

  9. 9

    Rechberger, W. et al. Opt. Commun. 220, 137–141 (2003).

    ADS  Article  Google Scholar 

  10. 10

    Mühlschlegel, P., Eisler, H.-J., Martin, O. J. F., Hecht, B. & Pohl, D. W. Science 308, 1607–1609 (2005).

    ADS  Article  Google Scholar 

  11. 11

    Schuck, P. J., Fromm, D. P., Sundaramurthy, A., Kino, G. S. & Moerner, W. E. Phys. Rev. Lett. 94, 017402 (2005).

    ADS  Article  Google Scholar 

  12. 12

    Levene, M. J. et al. Science 299, 682–686 (2003).

    ADS  Article  Google Scholar 

  13. 13

    Anger, P., Bharadwaj, P. & Novotny, L. Phys. Rev. Lett. 96, 113002 (2006).

    ADS  Article  Google Scholar 

  14. 14

    Kühn, S., Håkanson, U., Rogobete, L. & Sandoghdar, V. Phys. Rev. Lett. 97, 017402 (2006).

    ADS  Article  Google Scholar 

  15. 15

    Farahani, J. N., Pohl, D. W., Eisler, H.-J. & Hecht, B. Phys. Rev. Lett. 95, 017402 (2005).

    ADS  Article  Google Scholar 

  16. 16

    Höppener, C. & Novotny, L. Nano Lett. 8, 642–646 (2008).

    ADS  Article  Google Scholar 

  17. 17

    Frey, H. G., Witt, S., Felderer, K. & Guckenberger, R. Phys. Rev. Lett. 93, 200801 (2004).

    ADS  Article  Google Scholar 

  18. 18

    Taminiau, T. H., Moerland, R. J., Segerink, F. B., Kuipers, L. & van Hulst, N. F. Nano Lett. 7, 28–33 (2007).

    ADS  Article  Google Scholar 

  19. 19

    Taminiau, T. H., Moerland, R. J., Segerink, F. B., Kuipers, L. & van Hulst, N. F. J. Opt. A 9, S315–S321 (2007).

    Article  Google Scholar 

  20. 20

    Brehm, M., Taubner, T., Hillenbrand, R. & Keilmann, F. Nano Lett. 6, 1307–1310 (2006).

    ADS  Article  Google Scholar 

  21. 21

    Pettinger, B., Ren, B., Picardi, G., Schuster, R. & Ertl, G. Phys. Rev. Lett. 92, 096101 (2004).

    ADS  Article  Google Scholar 

  22. 22

    Hell. S. W. Science 316, 1153–1158 (2007).

    ADS  Article  Google Scholar 

  23. 23

    Betzig, E. et al. Science 313, 1642–1645 (2006).

    ADS  Article  Google Scholar 

  24. 24

    Rust, M. J., Bates, M. & Zhuang, X. Nature Methods 3, 793–795 (2006).

    Article  Google Scholar 

  25. 25

    Eddin, M. Nature Rev. Mol. Cell Biol. 4, 414–418 (2003).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Garcia-Parajo, M. Optical antennas focus in on biology. Nature Photon 2, 201–203 (2008). https://doi.org/10.1038/nphoton.2008.37

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing