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Cancer therapy

Neutrophils traffic in cancer nanodrugs

Nature Nanotechnology volume 12, pages 616–618 (2017)Cite this article

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Neutrophils loaded with cationic liposomal paclitaxel migrate across the blood/brain barrier to deliver chemotherapeutic nanoparticles in the inflamed post-surgical tumour margin.

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Figure 1: Schematic of the neutrophil-mediated drug-delivery system for preventing glioma recurrence after surgical resection in mice.

References

  1. Van Meir, E. G. et al. CA Cancer J. Clin. 60, 166–193 (2010).

    Article  Google Scholar 

  2. Van Meir, E. G., Sawamura, Y, Diserens, A. C., Hamou, M. F. & de Tribolet, N. Cancer Res. 50, 6683–6688 (1990).

    CAS  Google Scholar 

  3. Desbaillets, I., Diserens, A.-C., de Tribolet, N., Hamou, M.-F. & Van Meir, E. G. J. Exp. Med. 186, 1201–1212 (1997).

    Article  CAS  Google Scholar 

  4. Osuka, S. & Van Meir, E. G. J. Clin. Invest. 127, 415–426 (2017).

    Article  Google Scholar 

  5. Xue, J. et al. Nat. Nanotech. 12, 692–700 (2017).

    Article  CAS  Google Scholar 

  6. Binello, E. & Germano, I. M. Neuro. Oncol. 14, 256–265 (2012).

    Article  CAS  Google Scholar 

  7. Aboody, K. S. et al. Sci. Transl. Med. 5, 184ra59 (2013).

    Article  Google Scholar 

  8. Kolaczkowska, E. & Kubes, P. Nat. Rev. Immunol. 13, 159–175 (2013).

    Article  CAS  Google Scholar 

  9. Fossati, G. et al. Acta Neuropathol. 98, 349–354 (1999).

    Article  CAS  Google Scholar 

  10. Allen, M., Bjerke, M., Edlund, H., Nelander, S. & Westermark, B. Sci. Transl. Med. 8, 354re3 (2016).

    Article  Google Scholar 

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Authors and Affiliations

  1. Departments of Neurosurgery and Hematology & Medical Oncology, Satoru Osuka and Erwin G. Van Meir are in the Laboratory of Molecular Neuro-Oncology, School of Medicine and Winship Cancer Institute, Emory University, 1365C Clifton Rd. N.E., C5078, Atlanta, Georgia 30322, USA,

    Satoru Osuka & Erwin G. Van Meir

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  1. Satoru Osuka
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  2. Erwin G. Van Meir
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Correspondence to Satoru Osuka or Erwin G. Van Meir.

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Osuka, S., Van Meir, E. Neutrophils traffic in cancer nanodrugs. Nature Nanotech 12, 616–618 (2017). https://doi.org/10.1038/nnano.2017.82

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