Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

DNA computing

Spatially localized DNA domino

Fast and scalable molecular logic circuits have been constructed by spatially localizing DNA hairpins on DNA origami scaffolds.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Principle of DNA domino circuits.


  1. 1

    Rothemund, P. W. K. Nature 440, 297–302 (2006).

    CAS  Article  Google Scholar 

  2. 2

    Chatterjee, G., Dalchau, N., Muscat, R. A., Phillips, A. & Seelig, G. Nat. Nanotech. 12, 920–927 (2017).

    CAS  Article  Google Scholar 

  3. 3

    Padirac, A., Fujii, T. & Rondelez, Y. Curr. Opin. Biotechnol. 24, 575–580 (2013).

    CAS  Article  Google Scholar 

  4. 4

    Loose, M. et al. Nat. Struct. Mol. Biol. 18, 577–583 (2011).

    CAS  Article  Google Scholar 

  5. 5

    Dirks, R. M. & Pierce, N. A. Proc. Natl Acad. Sci. USA 101, 15275–15278 (2004).

    CAS  Article  Google Scholar 

  6. 6

    Qian, L., Winfree, E. & Bruck, J. Nature 475, 368–372 (2011).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding authors

Correspondence to André Estevez-Torres or Yannick Rondelez.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Estevez-Torres, A., Rondelez, Y. Spatially localized DNA domino. Nature Nanotech 12, 842–843 (2017).

Download citation

Further reading


Quick links

Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research