Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Protein machines

An open and shut cage

By incorporating photosensitive switches, protein nanocages can be made to open and close on demand with light.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Turning an ATP-driven chaperonin into a light-driven nanocage.


  1. Ishii, D. et al. Nature 423, 628–632 (2003).

    Article  CAS  Google Scholar 

  2. Muramatsu, S. et al. J. Am. Chem. Soc. 128, 3764–3769 (2006).

    Article  CAS  Google Scholar 

  3. Zhang, J. et al. Nature 463, 379–383 (2010).

    Article  CAS  Google Scholar 

  4. Hoersch, D., Roh, S.-H., Chiu, W. & Kortemme, T. Nature Nanotech. 8, 928–932 (2013).

    Article  CAS  Google Scholar 

  5. Beharry, A. A. et al. Biochem. 51, 6421–6431 (2013).

    Article  Google Scholar 

  6. Samanta, S. et al. J. Am. Chem. Soc. 135, 9777–9784 (2013).

    Article  CAS  Google Scholar 

  7. Goodsell, D. S. & Olson, A. J. Annu. Rev. Biophys. Biomol. Struct. 29, 105–153 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to G. Andrew Woolley.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Woolley, G. An open and shut cage. Nature Nanotech 8, 892–893 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research