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Single-molecule detection

Breaking the concentration barrier

The combination of a plasmonic nanoantenna and a nanoaperture has merged fluorescence enhancement and spatial confinement to enable single-molecule detection at biologically relevant concentrations.

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Figure 1: Nanophotonic approaches to enhance single-molecule detection.


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Correspondence to Philip Tinnefeld.

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Tinnefeld, P. Breaking the concentration barrier. Nature Nanotech 8, 480–482 (2013).

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