Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Nanoparticles

Pushed off target with proteins

The formation of a protein corona around the surface of a nanoparticle can alter its targeting capabilities.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Schematic diagram of transferrin-conjugated nanoparticles targeting transferrin receptors in the presence of serum proteins2.

References

  1. Cedervall, T. et al. Proc. Natl Acad. Sci. USA 104, 2050–2055 (2007).

    CAS  Google Scholar 

  2. Salvati, A. et al. Nature Nanotech. 8, 137–143 (2013).

    Article  CAS  Google Scholar 

  3. Maeda, H. et al. Adv. Drug Deliv. Rev. http://dx.doi.org/10.1016/j.addr.2012.10.002 (2012).

  4. Jain, R. K. Adv. Drug Deliv. Rev. 64, 353–365 (2012).

    Article  Google Scholar 

  5. Duncan, R. & Richardson, S. Mol. Pharmaceutics 9, 2380–2402 (2012).

    Article  CAS  Google Scholar 

  6. Ruoslahti, E. et al. J. Cell Biol. 188, 759–768 (2010).

    Article  CAS  Google Scholar 

  7. Allen, T. M. & Cullis, P. R. Adv. Drug Deliv. Rev. & http://dx.doi.org/10.1016/j.addr.2012.09.037 (2012).

  8. Koshkaryev, A. et al. Adv. Drug Deliv. Rev. http://dx.doi.org/10.1016/j.addr.2012.08.009 (2012).

  9. Duncan, R. & Gaspar, R. Mol. Pharmaceutics 8, 2101–2141 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rogério Gaspar.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gaspar, R. Pushed off target with proteins. Nature Nanotech 8, 79–80 (2013). https://doi.org/10.1038/nnano.2013.11

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nnano.2013.11

This article is cited by

Search

Quick links

Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research