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Getting close to the action

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Two independent groups have demonstrated that nanoscale electrodes can record action potentials in neurons and cardiac muscle cells, and a third group has shown that nanowire field-effect transistors can make electrical measurements on biological materials with unprecedented spatial resolution.

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Figure 1: Getting inside cells.

Change history

  • 22 February 2012

    In the News & Views article 'Getting close to the action' originally published online (Nature Nanotech. 2012), the signal-to-noise ratio determined by Cui and co-workers was given incorrectly as '7'; it should have read 'over 100'. This error has now been corrected in all versions of the News & Views article.'


  1. Duan, X. et al. Nature Nanotech. (2011).

  2. Robinson, J. T. et al. Nature Nanotech. (2012).

  3. Xie, C., Lin, Z., Hanson, L., Cui, Y. & Cui, B. Nature Nanotech. (2012).

  4. Shalek, A. K. et al. Proc. Natl Acad. Sci. USA 107, 1870–1875 (2010).

    Article  CAS  Google Scholar 

  5. Araque, A., Parpura, V., Sanzgiri, R. P. & Haydon, P. G. Eur. J. Neurosci. 10, 2129–2142 (1998).

    Article  CAS  Google Scholar 

  6. Katz, L. C. & Dalva, M. B. J. Neurosci. Methods 54, 205–218 (1994).

    Article  CAS  Google Scholar 

  7. Mancuso, J. J. et al. Exp. Physiol. 96, 26–33 (2010).

    Article  Google Scholar 

  8. Xie, C. et al. Nano Lett. 10, 4020–4024 (2010).

    Article  CAS  Google Scholar 

  9. Keefer, E. W., Botterman, B. R., Romero, M. I., Rossi, A. F. & Gross, G. W. Nature Nanotech. 3, 434–439 (2008).

    Article  CAS  Google Scholar 

  10. Yu, Z. et al. Nano Lett. 7, 2188–2195 (2007).

    Article  CAS  Google Scholar 

  11. Bekyarova, E. et al. J. Biomed. Nanotechnol. 1, 3–17 (2005).

    Article  CAS  Google Scholar 

  12. Patolsky, F. et al. Science 313, 1100–1104 (2006).

    Article  CAS  Google Scholar 

  13. Cohen-Karni, T., Timko, B. P., Weiss, L. E. & Lieber, C. M. Proc. Natl Acad. Sci. USA 106, 7309–7313 (2009).

    Article  CAS  Google Scholar 

  14. Tian, B. et al. Science 329, 830–834 (2010).

    Article  CAS  Google Scholar 

  15. Stuart, G. J., Dodt, H. U. & Sakmann, B. Pflugers Arch 423, 511–518 (1993).

    Article  CAS  Google Scholar 

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Correspondence to Vladimir Parpura.

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Parpura, V. Getting close to the action. Nature Nanotech 7, 143–145 (2012).

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