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Nanotoxicology

Damaging DNA from a distance

Nanoparticles can have an adverse impact on cells, even when there is a barrier between the cells and the source of the nanoparticles. Both direct and indirect effects should therefore be included in assessments of nanoparticle safety.

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Figure 1: Nanoparticles can damage DNA without crossing barriers.

References

  1. Lewinski, N. et al. Small 4, 26–49 (2008).

    CAS  Article  Google Scholar 

  2. Singh, N. et al. Biomaterials 30, 3891–3914 (2009).

    CAS  Article  Google Scholar 

  3. Landsiedel, R. et al. Mutat. Res. 681, 241–258 (2009).

    CAS  Article  Google Scholar 

  4. Bhabra, G. et al. Nature Nanotech. 4, 876–883 (2009).

    CAS  Article  Google Scholar 

  5. Hales, B. F. Curr. Opin. Genet. Dev. 15, 234–240 (2005).

    CAS  Article  Google Scholar 

  6. Liu, F. et al. Am. J. Physiol. 273, C1596–1604 (1997).

    CAS  Article  Google Scholar 

  7. Saunders, M. Nanomed. Nanobiotechnol. 1, 671–684 (2009).

    CAS  Article  Google Scholar 

  8. Tsuchiya, T. et al. FEBS Lett. 393, 139–145 (1981).

    Article  Google Scholar 

  9. Chan, W.-H. Acta Pharmacol. Sin. 28, 259–266 (2008).

    Article  Google Scholar 

  10. Park, M. V. D. Z. et al. Toxicol. Appl. Pharmacol. 240, 108–116 (2009).

    CAS  Article  Google Scholar 

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Myllynen, P. Damaging DNA from a distance. Nature Nanotech 4, 795–796 (2009). https://doi.org/10.1038/nnano.2009.365

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  • DOI: https://doi.org/10.1038/nnano.2009.365

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