Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Damaging DNA from a distance

Nanoparticles can have an adverse impact on cells, even when there is a barrier between the cells and the source of the nanoparticles. Both direct and indirect effects should therefore be included in assessments of nanoparticle safety.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Nanoparticles can damage DNA without crossing barriers.


  1. Lewinski, N. et al. Small 4, 26–49 (2008).

    Article  CAS  Google Scholar 

  2. Singh, N. et al. Biomaterials 30, 3891–3914 (2009).

    Article  CAS  Google Scholar 

  3. Landsiedel, R. et al. Mutat. Res. 681, 241–258 (2009).

    Article  CAS  Google Scholar 

  4. Bhabra, G. et al. Nature Nanotech. 4, 876–883 (2009).

    Article  CAS  Google Scholar 

  5. Hales, B. F. Curr. Opin. Genet. Dev. 15, 234–240 (2005).

    Article  CAS  Google Scholar 

  6. Liu, F. et al. Am. J. Physiol. 273, C1596–1604 (1997).

    Article  CAS  Google Scholar 

  7. Saunders, M. Nanomed. Nanobiotechnol. 1, 671–684 (2009).

    Article  CAS  Google Scholar 

  8. Tsuchiya, T. et al. FEBS Lett. 393, 139–145 (1981).

    Article  Google Scholar 

  9. Chan, W.-H. Acta Pharmacol. Sin. 28, 259–266 (2008).

    Article  Google Scholar 

  10. Park, M. V. D. Z. et al. Toxicol. Appl. Pharmacol. 240, 108–116 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Myllynen, P. Damaging DNA from a distance. Nature Nanotech 4, 795–796 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research