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Bioimaging

Second window for in vivo imaging

Nature Nanotechnology volume 4, pages 710–711 (2009)Cite this article

Enhanced fluorescence from carbon nanotubes and advances in near-infrared cameras have opened up a new wavelength window for small animal imaging.

In 2003, simulations and modelling studies4 of optical imaging in turbid media such as tissue or blood suggested that it would be possible to improve signal-to-noise ratios by over 100-fold by using quantum dot fluorophores that emit light at 1,320 nm (instead of 850 nm). However, the lack of biocompatible fluorescent probes in this second near-infrared window between 1,000 and 1,350 nm has prevented the use of this highly sensitive spectral range for in vivo imaging.

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Figure 1: Optical windows in biological tissues.

SMITH/MANCINI/NIE

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Authors and Affiliations

  1. Michael C. Mancini and Shuming Nie are in the Departments of Biomedical Engineering and Chemistry, Andrew M. Smith, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2007, Atlanta, Georgia 30322, USA.,

    Andrew M. Smith, Michael C. Mancini & Shuming Nie

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  1. Andrew M. Smith
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  2. Michael C. Mancini
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  3. Shuming Nie
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Correspondence to Shuming Nie.

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Smith, A., Mancini, M. & Nie, S. Second window for in vivo imaging. Nature Nanotech 4, 710–711 (2009). https://doi.org/10.1038/nnano.2009.326

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