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Silence the target

A new formulation of magnetic nanoparticles steered to cells by external magnets can deliver nucleic acids to turn off the growth of tumour blood vessels in mice.

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Figure 1: Magnetic targeting in drug and gene delivery.



  1. Namiki, Y. et al. Nature Nanotech. 4, 598–606 (2009).

    Article  CAS  Google Scholar 

  2. Olive, K. P. et al. Science 324, 1457–1461 (2009).

    Article  CAS  Google Scholar 

  3. Tseng, Y. C. et al. Adv. Drug Deliv. Rev. 61, 721–731 (2009).

    Article  CAS  Google Scholar 

  4. Medarova, Z. et al. Nature Med. 13, 372–377 (2007).

    Article  CAS  Google Scholar 

  5. Oh, Y. K. & Park, T. G. Adv. Drug Deliv. Rev. 61, 850–862 (2009).

    Article  CAS  Google Scholar 

  6. Alksne, J. F. et al. J. Neurosurg. 25, 516–525 (1966).

    Article  CAS  Google Scholar 

  7. Widder, K. J. et al. Proc. Soc. Exp. Biol. Med. 158, 141–146 (1978).

    Article  CAS  Google Scholar 

  8. Lubbe, A. S. et al. Cancer Res. 56, 4686–4693 (1996).

    CAS  Google Scholar 

  9. Lemke, A. J. et al. Eur. Radiol. 14, 1949–1955 (2004).

    Article  Google Scholar 

  10. Mykhaylyk, O. et al. Nature Protoc. 2, 2391–2411 (2007).

    Article  CAS  Google Scholar 

  11. Hood, J. D. et al. Science 296, 2404–2407 (2002).

    Article  CAS  Google Scholar 

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Competing interests

The author is a co-founder of the biotech company OZ Biosciences (OZB), Marseille, France. OZB develops and markets nanomagnetic reagents for nucleic acid delivery. The authors whose paper is discussed in this News & Views have used such reagents from OZB and have shown that their own reagents are superior.

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Plank, C. Silence the target. Nature Nanotech 4, 544–545 (2009).

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