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DNA nanotechnology

Geometric sorting boards

Nature Nanotechnology volume 4, pages 543–544 (2009)Cite this article

DNA origami tiles can bind to shape-complementary sites on lithographically patterned surfaces.

A common childhood toy involves matching geometric shapes, such as triangles, circles and squares, with the corresponding holes in a flat board. Success teaches the child who is using the toy about shape-dependent discrimination and shape complementarity. Similar principles can be exploited in nanotechnology, where the lock-and-key approach is attractive for building structures and devices on surfaces containing templates etched with lithography or some other top-down fabrication process. However, applying these strategies to control and create surface mosaics has proven difficult, particularly as the size of the shapes and templates is reduced.

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Figure 1: Surface patterning with DNA tiles.

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Authors and Affiliations

  1. David W. Grainger is in the Department of Pharmaceutics and Pharmaceutical Chemistry and the Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112-5820, USA. david.grainger@utah.edu,

    David W. Grainger

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  1. David W. Grainger
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Grainger, D. Geometric sorting boards. Nature Nanotech 4, 543–544 (2009). https://doi.org/10.1038/nnano.2009.249

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