Understanding and controlling the transport of water across nanochannels is of great importance for designing novel molecular devices, machines and sensors and has wide applications1,2,3,4,5,6,7,8,9, including the desalination of seawater5. Nanopumps driven by electric or magnetic fields can transport ions10,11 and magnetic quanta12, but water is charge-neutral and has no magnetic moment. On the basis of molecular dynamics simulations, we propose a design for a molecular water pump. The design uses a combination of charges positioned adjacent to a nanopore and is inspired by the structure of channels in the cellular membrane that conduct water in and out of the cell (aquaporins). The remarkable pumping ability is attributed to the charge dipole-induced ordering of water confined in the nanochannels13,14, where water can be easily driven by external fields in a concerted fashion. These findings may provide possibilities for developing water transport devices that function without osmotic pressure or a hydrostatic pressure gradient.
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Whitesides, G. M. The origins and the future of microfluidics. Nature 442, 368–373 (2006).
Whitby, M. & Quirk, N. Fluid flow in carbon nanotubes and nanopipes. Nature Nanotech. 2, 87–94 (2007).
Squires, T. M. & Quake, S. R. Microfluidics: fluid physics at the nanoliter scale. Rev. Mod. Phys. 77, 977–1026 (2005).
Regan, B. C., Aloni. S., Ritchie, R. O., Dahmen, U. & Zettl, A. Carbon nanotubes as nanoscale mass conveyors. Nature 428, 924–927 (2004).
Service, R. F. Desalination freshens up. Science 313, 1088–1090 (2006).
Holt, J. K. et al. Fast mass transport through sub-2-nanometer carbon nanotubes. Science 312, 1034–1037 (2006).
Bourlon, B., Wong, J., Miko, C., Forro, L. & Bockrath, M. A nanoscale probe for fluidic and ionic transport. Nature Nanotech. 2, 104–107 (2007).
Besteman, K., Lee, J. O., Wiertz, F. G. M., Heering, H. A. & Dekker, C. Enzyme-coated carbon nanotubes as single-molecule biosensors. Nano Lett. 3, 727–730 (2003).
Ghosh, S., Sood, A. K. & Kumar, N. Carbon nanotube flow sensors. Science 299, 1042–1044 (2003).
Fan, R., Yue, M., Karnik, R., Majumdar, A. & Yang, P. D. Polarity switching and transient responses in single nanotube nanofluidic transistors. Phys. Rev. Lett. 95, 086607 (2005).
Siwy, Z. & Fulinski, A. Fabrication of a synthetic nanopore ion pump. Phys. Rev. Lett. 89, 198103 (2002).
Cole, D. et al. Ratchet without spatial asymmetry for controlling the motion of magnetic flux quanta using time-asymmetric drives. Nature Mater. 5, 305–311 (2006).
Hummer, G., Rasaiah, J. C. & Noworyta, J. P. Water conduction through the hydrophobic channel of a carbon nanotube. Nature 414, 188–190 (2001).
Li, J. Y. et al. Electrostatic gating of a nanometer water channel. Proc. Natl Acad. Sci. USA 104, 3687–3692 (2007).
Zhu, F. Q. & Schulten, K. Water and proton conduction through carbon nanotubes as models for biological channels. Biophys. J. 85, 236–244 (2003).
de Gennes, P. G., Brochard-Wyart, F. & Quere, D. Capillarity and Wetting Phenomena (Springer, New York, 2003).
Chaudhury, M. K. & Whitesides, G. M. How to make water run uphill. Science 256, 1539–1541 (1992).
Linke, H. et al. Self-propelled Leidenfrost droplets. Phys. Rev. Lett. 96, 154502 (2006).
Beckstein, O. & Sansom, M. S. P. Liquid–vapor oscillations of water in hydrophobic nanopores. Proc. Natl Acad. Sci. USA 100, 7063–7068 (2003).
Majumder, M., Chopra, N., Andrews, R. & Hinds, B. J. Enhanced flow in carbon nanotubes. Nature 438, 44 (2005).
Reiter, G. et al. Anomalous behavior of proton zero point motion in water confined in carbon nanotubes. Phys. Rev. Lett. 9724, 7801 (2006).
Sun, L. & Crooks, R. Single carbon nanotube membranes: a well-defined model for studying mass transport through nanoporous materials. J. Am. Chem. Soc. 122, 12340–12345 (2000).
Tenne, R. Inorganic nanotubes and fullerene-like nanoparticles. Nat. Nanotechnol. 1, 103–111 (2006).
Joseph, S., Mashl, R. J., Jakobsson, E. & Arulu, N. R. Electrolytic transport in modified carbon nanotubes. Nano Lett. 3, 1399–1403 (2003).
Zeidel, M. L. et al. Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin channel-forming integral protein in proteoliposomest. Biochemistry 33, 1606–1615 (1992).
de Groot, B. L. & Grubmüller, H. Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF. Science 294, 2353–2357 (2001).
Hess, B. et al. Gromacs-3.3 (Department of Biophysical Chemistry, University of Groningen, 2005).
Darden, T. A., York, D. M. & Pedersen, L. G. Particle mesh Ewald: An N·log(N) method for Ewald sums in large systems. J. Chem. Phys. 98, 10089–10092 (1993).
Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W. & Klein, M. L. Comparison of simple potential functions for simulating liquid water. J. Chem. Phys. 79, 926–935 (1983).
Longhurst, M. J. & Quirke, N. The environmental effect on the radial breathing mode of carbon nanotubes in water. J. Chem. Phys. 124, 234708 (2006).
We thank P. A. Pincus, D. Bensimon, Ruhong Zhou, Chunhai Fan and Jun Yan for helpful discussions. This work was supported by grants from Chinese Academy of Sciences, the National Science Foundation of China under grants nos. 10474109 and 10674146, the National Basic Research Program of China under grant nos. 2007CB936000, 2006CB933000 and 2006CB708612, and Shanghai Supercomputer Center of China.
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Gong, X., Li, J., Lu, H. et al. A charge-driven molecular water pump. Nature Nanotech 2, 709–712 (2007). https://doi.org/10.1038/nnano.2007.320
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